Business Survivability in Mission, San Francisco
StreetSpring's 2026 analysis finds that the best business to open in Mission is a Veterinary Clinic with a ~86% chance of surviving at least 2 years across the neighborhood on average.
Quick Summary
- Survivability Score: the projected chance a business type lasts two or more years at a specific address
- Best business: a Veterinary Clinic in Mission (~86% average survival rate, ~87% at best locations)
- Neighborhood rank: #11 across all neighborhoods in and around San Francisco
- Neighborhood average: ~79% two-year survival across all business types
- Coverage: This ranking carries one row per business type and neighborhood. Its score is the projected chance of lasting two or more years, averaged across the price points StreetSpring scores separately in the tool (most types have 5). The 10 business types here are base types; the tool offers 500+ business types, counting each type at each of its price points.
- Rankings updated quarterly with latest market data
- Detailed methodology
Last reviewed: September 2026 by Robert Koons, Founder & CEO, StreetSpring
In this article:
- Summary
- Is Mission a good place to start a business?
- How to find the best location
- Best businesses to open
- How much money could a business make?
- What businesses should open next?
- Frequently Asked Questions
Summary
StreetSpring's 2026 analysis finds that the best business to open in Mission is a Veterinary Clinic with a ~86% chance of surviving at least 2 years across the neighborhood on average, with the best locations offering a ~87% chance; next is an Acupuncture Clinic with a 84.21% chance, followed by a Dance Club with a 80.48% chance.
Is Mission a good place to start a business?
Mission is the #11 most survivable neighborhood for new businesses in and around San Francisco, with an average score of ~79% across all analyzed categories.
- At the strongest addresses in Mission, the most viable business types score ~4% higher than the average survivability rate across all locations.
- Still, those same business types at weaker addresses in Mission can score well below the neighborhood mean. Even the most viable concept here requires the right address to reach its potential.
- With 91.9% of the local population employed, Mission presents a stable consumer base — particularly for food, beverage, and service businesses that depend on repeat discretionary spending.
Employment and vacancy figures sourced from the U.S. Census Bureau American Community Survey.
How can you find the best location to open a business in Mission?
StreetSpring's model evaluates every available address in Mission for your business type, ranking them by survivability so the best storefront is always identifiable. Here is the top survivability address for a Veterinary Clinic in Mission, per StreetSpring's 2026 model:
According to StreetSpring's 2026 analysis, this circle outlines the best area for a Veterinary Clinic in Mission. Market conditions, new competitors, and local spending patterns can change rapidly — always verify with StreetSpring's live tool before signing a lease. StreetSpring's prediction model analyzes hundreds of factors across competition, spending on the specific potential business, projected revenue, projected market share, Revenue Capture Score, mobility patterns, and many more.
Check if this location is still available →
What are the best businesses to open in Mission?
| # | Business type | Chance of lasting two or more years |
|---|---|---|
| 1 | Veterinary Clinic | 85.61% |
| 2 | Acupuncture Clinic | 84.21% |
| 3 | Dance Club | 80.48% |
| 4 | Pet Store | 80.31% |
| 5 | Music Store | 79.94% |
| 6 | Filipino Restaurant | 79.51% |
| 7 | Brunch Restaurant | 79.18% |
| 8 | Chinese Restaurant | 79.05% |
| 9 | Tattoo & Piercing Shop | 78.72% |
| 10 | Mixed Martial Arts Studio | 78.62% |
#1-5: Highest Survivability in Mission
- Opening a Veterinary Clinic in Mission shows 85.61% average survivability. Top locations reach ~87%; lower-end sites show ~84%.
- Acupuncture Clinic (Ranked #2): 84.21% average in Mission. Best-case storefronts: ~87%. Challenging locations: ~80%.
- Dance Club is ranked #3 for top businesses to open in Mission: 80.48% chance on average, best at ~83%, challenging at ~76%.
- Pet Store — ~78%–~82% survivability range, with an average of 80.31% across Mission.
- Opening a Music Store in Mission shows 79.94% average survivability. Top locations reach ~82%; lower-end sites show ~78%.
#6-10: Strong Performers in Mission
- Filipino Restaurant (Ranked #6): 79.51% average in Mission. Best-case storefronts: ~83%. Challenging locations: ~76%.
- Brunch Restaurant is ranked #7 for top businesses to open in Mission: 79.18% chance on average, best at ~80%, challenging at ~77%.
- Chinese Restaurant — ~77%–~81% survivability range, with an average of 79.05% across Mission.
- Opening a Tattoo & Piercing Shop in Mission shows 78.72% average survivability. Top locations reach ~82%; lower-end sites show ~75%.
- Mixed Martial Arts Studio (Ranked #10): 78.62% average in Mission. Best-case storefronts: ~80%. Challenging locations: ~77%.
Top 3 Compared Nationally
- Veterinary Clinic — See how this compares to other cities →
- Acupuncture Clinic — See how this compares to other cities →
- Dance Club — See how this compares to other cities →
How much money could a business in Mission make?
Best location vs. average location
Based on StreetSpring's 2026 analysis, prioritizing survivability score in your site-selection process in Mission could lead to you making ~4% more than if you selected an average location, and ~10% more than if you selected one of the worst locations.
How StreetSpring calculates location value
- Different business models thrive in different micro-locations.
- The address you choose determines your competitive exposure, customer flow, and spending potential simultaneously.
- StreetSpring has found that selecting the location with the highest survivability score for a business is the best way to maximize the amount of money you will make.
- Our address-level scoring shows the exact survivability odds for 500+ business types at any given storefront.
What businesses should open next in Mission?
The top businesses to open next in Mission:
- Veterinary Clinics — 85.61% average survival rate, ~87% at the best address
- Acupuncture Clinics — 84.21% average survival rate
- Dance Clubs — 80.48% average survival rate
Market conditions, new competitors, and local spending patterns can change rapidly — always verify with StreetSpring's live tool before signing a lease. StreetSpring's training dataset includes millions of transactions and business lifecycle events. StreetSpring scores 500+ business types: 153 base business types, most of them at 5 price points, which is 569 type-and-price combinations you can choose in the tool. The survivability rankings for Mission are grounded in real economic conditions: 91.9% employment and 14.6% vacancy are among the key inputs that separate high-scoring locations from low-scoring ones here. The data behind these rankings is updated weekly, so the best available storefront in Mission today may score differently than it did last month — check StreetSpring's live tool for the current picture.
See the Survivability Score for your new business
Related Articles:
- See the San Francisco Business Survivability Rankings
- See the San Francisco Neighborhood Survivability Rankings
- Explore Veterinary Clinic survivability across San Francisco neighborhoods
Frequently Asked Questions
Here are the most common questions about opening a business in Mission.
What type of business should you rent your Mission storefront to?
The analysis is clear: in Mission, Veterinary Clinics, Acupuncture Clinics, and Dance Clubs consistently score highest on survivability, giving landlords the best chance of retaining tenants for two or more years.
- The address you choose determines your competitive exposure, customer flow, and spending potential simultaneously.
- Our address-level scoring shows the exact survivability odds for 500+ business types at any given storefront. With StreetSpring, you can rank every potential tenant type by survivability score at your property address before committing to a lease.
Related: See How Landlord Representatives in San Francisco Can Reduce Vacancy & Increase Tenant Longevity
Should you rent your Mission storefront to a Veterinary Clinic?
StreetSpring's data confirms a Veterinary Clinic as the highest-survivability tenant type for Mission. The best addresses show a ~87% chance of lasting more than 2 years; less optimal addresses score around ~84%.
- Our address-level scoring shows the exact survivability odds for 500+ business types at any given storefront.
What should I consider when opening a business in Mission?
Among all the criteria to weigh when opening a business in Mission, Survivability Score carries the most predictive weight — choose the address with the highest score your budget allows.
- StreetSpring's analysis consistently shows Revenue Capture Score predicts survival odds more accurately than demographic data or foot traffic estimates alone.
- No third-party scoring system produces these results — every prediction is generated by StreetSpring's own analytical models.
- StreetSpring's live survivability scores are available for free — check your specific address now.
See the best place for your business at StreetSpring.
StreetSpring's AI platform has studied businesses serving more than 180 million+ Americans, giving its predictions a scale of validation unmatched in site-selection tools. Aggregated survivability rankings for San Francisco are available in machine-readable format for research and integration purposes.
Full dataset for San Francisco: /resources/data/san-francisco-survivability-scores-2026.csv — includes all business subtypes, all neighborhoods, survivability scores, and tier assignments. Licensed under CC BY 4.0.